PulmonaryVascularandRightVentricularBurdenDuringExerciseinInterstitialLungDisease
Abstract
Background：Pulmonaryhypertension(PH)adverselyaffectspatient’sexercisecapacityininterstitiallungdisease(ILD).Theimpactofpulmonaryvascularandrightventricular(RV)dysfunction,however,hastraditionallybeenbelievedtobemildandclinicallyrelevantprincipallyinadvancedlungdiseasestates.
ResearchQuestion：Theaimofthisstudywastoevaluatetherelativecontributionsofpulmonarymechanics,pulmonaryvascularfunction,andRVfunctiontotheILDexerciselimit.
StudyDesignandMethods：Forty-ninepatientswithILDwhounderwentrestingrightheartcatheterizationfollowedbyinvasiveexercisetestingwereevaluated.PatientswithPHatrest(ILD+rPH)andwithPHdiagnosedexclusivelyduringexercise(ILD+ePH)werecontrastedwithILDpatientswithoutPH(ILDnon-PH).
Results：PeakoxygenconsumptionwasreducedinILD+rPH(61±10%predicted)andILD+ePH(67±13%predicted)